We developed a dedicated collection of over 7,800 drug-like screening compounds optimized for high-throughput screening against shared inflammatory and immune signaling pathways implicated in psoriasis, psoriatic arthritis, rheumatoid arthritis and related conditions. Additionally, a dermal-optimized subset was designed to exhibit physicochemical properties conducive to efficient skin penetration.

Our new assay-ready set comprises 1,700 fluorinated fragment-like compounds, optimized for ¹⁹F NMR ligand-based fragment screening, ensuring high structural diversity with varied local fluorine environments, while maintaining strong suitability for FBDD. The fragments are organized into 170 predefined fluorine fragment cocktails, with 10 compounds per cocktail, strategically pooled to maximize separation of ¹⁹F chemical shifts and enable clear, unambiguous interpretation of NMR screening data.

Our cheminformatics team has prepared a specialized screening set of 2,600 chemically diverse, synthetically accessible molecules with high SOS1-binding potential in the RAS-MAPK signaling pathway, low assay-interference risk, and thus positive suitability for downstream medicinal-chemistry optimization in oncology drug discovery.

Our ADME-optimized subset features 120,000 drug-like screening compounds with predicted favorable ADME characteristics. It is distinctively focused on skin permeability, gastrointestinal absorption and blood-brain barrier penetration. Additionally, machine learning screening allowed us to select over 419,000 stock compounds to show reduced risk of CYP3A4, CYP2D6, and CYP2C9 inhibition, minimizing potential drug-drug interactions.

We picked out 700 drug-like screening compounds that modulate beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), the main initiator of amyloid-beta production to support Alzheimer's disease drug discovery programs targeting secretase-driven pathways.

Explore 8,000 carefully selected small molecules associated with key AD-related biological pathways, including amyloid-beta and tau pathology, neuroinflammation, mitochondrial dysfunction.

We offer 2,300 synthetically versatile fragments featuring structurally diverse poised scaffolds, selected proceeding from the concept of poised chemistry introduced by DSI and SGC for rapid analog synthesis, hit elaboration and SAR exploration in FBDD.

The Library includes over 18,300 small molecules targeting adenosine-related targets, histamine receptors, and other neurodegenerative pathways. Designed through advanced cheminformatics selection, it offers structural diversity and biological relevance for CNS and neuroinflammation research.