Fragments Library

Fragment-based Drug Discovery (FBDD) is a rapidly developing alternative to screening drug-like compounds. It starts with synthesizing and then screening fragment-based libraries composed of compounds that have lower molecular weight and lower molecular complexity than suggested by Lipinski Rule of 5. The process of synthesis is guided by a heuristic rule, which is called Rule of 3.

Life Chemicals Inc. offers original Fragment Library consisting of more than 31,000 lead-like, small MW (less than 300) and low cLogP (less than 3) compounds thus being the largest and most diverse fragment library on the market.  It includes 26,270 in-stock compounds available for immediate delivery and 4,945 tangible/virtual compounds that can be made upon your request. All the compounds are functionalized molecules that have at least 2 pharmacophors as well as handles suitable for building SAR. The library is available for cherry-picking, or we can create a diversity set according to customer’s requirements. Our library is very competitively priced and gets very good feedback from customers.

All compounds in Life Chemicals fragment library are at least 90% pure, with structural integrity validated by 400 MHz NMR and/or LC-MS. Analytical data for every compound are delivered upon request of the customer. Compounds can be supplied to any part of the world in containers of the customer’s choice as dry powders or DMSO solutions.  Containers are bar-coded and labeled according to the customer’s requirements.