The library was constructed on the basis of Life Chemicals Compound Collection of 385,000 compounds and Otava Stock Collection (70,000 compounds). Structure-activity relation analysis and PASS training set have been used for the library preparation. PASS training set consists of about 46,000 of biologically active compounds. They include about 16,000 already launched drugs and 30,000 drug-candidates under clinical or advanced preclinical testing now.